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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: P23528




USC-OGP 2-DE database:  P23528


P23528


General information about the entry
View entry in simple text format
Entry nameCOF1_HUMAN
Primary accession numberP23528
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Cofilin-1; AltName: Full=18 kDa phosphoprotein; Short=p18; AltName: Full=Cofilin, non-muscle isoform;.
Gene nameName=CFL1
Synonyms=CFL
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-5 {PLATELET 4-5}
Homo sapiens (Human)
PLATELET_4-5
  map experimental info
 
PLATELET_4-5

MAP LOCATIONS:
pI=4.96; Mw=14509



PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.61; Mw=18110
pI=5.96; Mw=18044



PLATELET_5-6 {PLATELET 5-6}
Homo sapiens (Human)
PLATELET_5-6
  map experimental info
 
PLATELET_5-6

MAP LOCATIONS:
pI=5.94; Mw=16532
pI=5.96; Mw=16532



PLATELET_6-11 {PLATELET 6-11}
Homo sapiens (Human)
PLATELET_6-11
  map experimental info
 
PLATELET_6-11

MAP LOCATIONS:
pI=5.93; Mw=18109
pI=6.03; Mw=18109
pI=6.12; Mw=18109
pI=6.89; Mw=17588
pI=6.99; Mw=17537
pI=7.22; Mw=17384
pI=7.84; Mw=17083
pI=7.95; Mw=17033



UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=5.27; Mw=14950
pI=8.49; Mw=13705

Cross-references
UniProtKB/Swiss-ProtP23528; COF1_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameCOF1_HUMAN
Primary accession numberP23528
Secondary accession number(s) B3KUQ1 Q53Y87 Q9UCA2
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on March 15, 2017 (version 195)
Name and origin of the protein
DescriptionRecName: Full=Cofilin-1; AltName: Full=18 kDa phosphoprotein; Short=p18; AltName: Full=Cofilin, non-muscle isoform;
Gene nameName=CFL1
Synonyms=CFL
Encoded onName=CFL1; Synonyms=CFL
Keywords3D-structure; Acetylation; Actin-binding; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Nucleus; Phosphoprotein; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLD00682; BAA00589.1; -; mRNA
EMBLU21909; AAA64501.1; -; mRNA
EMBLX95404; CAA64685.1; -; mRNA
EMBLBT006846; AAP35492.1; -; mRNA
EMBLAK097690; BAG53513.1; -; mRNA
EMBLCH471076; EAW74449.1; -; Genomic_DNA
EMBLBC011005; AAH11005.1; -; mRNA
EMBLBC012265; AAH12265.1; -; mRNA
EMBLBC012318; AAH12318.1; -; mRNA
EMBLBC018256; AAH18256.1; -; mRNA
CCDSCCDS8114.1; -; .
PIRS12632; S12632; .
RefSeqNP_005498.1; NM_005507.2; .
UniGeneHs.170622; -; .
PDB1Q8G; NMR; -; A=1-166
PDB1Q8X; NMR; -; A=1-166
PDB3J0S; EM; 9.00 A; M/N/O/P/Q/R/S/T/U/V/W/X=1-166
PDB4BEX; X-ray; 2.80 A; 1=1-166
PDB5HVK; X-ray; 3.50 A; B/D=2-166
PDB5L6W; X-ray; 2.53 A; C=1-166
PDBsum1Q8G; -; .
PDBsum1Q8X; -; .
PDBsum3J0S; -; .
PDBsum4BEX; -; .
PDBsum5HVK; -; .
PDBsum5L6W; -; .
ProteinModelPortalP23528; -; .
SMRP23528; -; .
BioGrid107499; 148; .
DIPDIP-33000N; -; .
IntActP23528; 76; .
MINTMINT-4999473; -; .
STRING9606.ENSP00000309629; -; .
ChEMBLCHEMBL1075129; -; .
DrugBankDB04147; Lauryl Dimethylamine-N-Oxide; .
iPTMnetP23528; -; .
PhosphoSitePlusP23528; -; .
SwissPalmP23528; -; .
BioMutaCFL1; -; .
DMDM116848; -; .
DOSAC-COBS-2DPAGEP23528; -; .
OGPP23528; -; .
REPRODUCTION-2DPAGEIPI00012011; -; .
SWISS-2DPAGEP23528; -; .
UCD-2DPAGEP23528; -; .
EPDP23528; -; .
PaxDbP23528; -; .
PeptideAtlasP23528; -; .
PRIDEP23528; -; .
TopDownProteomicsP23528; -; .
DNASU1072; -; .
EnsemblENST00000308162; ENSP00000309629; ENSG00000172757; .
EnsemblENST00000525451; ENSP00000432660; ENSG00000172757; .
GeneID1072; -; .
KEGGhsa:1072; -; .
CTD1072; -; .
DisGeNET1072; -; .
GeneCardsCFL1; -; .
H-InvDBHIX0009009; -; .
HGNCHGNC:1874; CFL1; .
HPACAB033687; -; .
HPACAB037077; -; .
HPAHPA053761; -; .
MIM601442; gene; .
neXtProtNX_P23528; -; .
OpenTargetsENSG00000172757; -; .
PharmGKBPA26423; -; .
eggNOGKOG1735; Eukaryota; .
eggNOGENOG41122P5; LUCA; .
GeneTreeENSGT00440000033289; -; .
HOGENOMHOG000039697; -; .
HOVERGENHBG000381; -; .
InParanoidP23528; -; .
KOK05765; -; .
PhylomeDBP23528; -; .
TreeFamTF328601; -; .
ReactomeR-HSA-114608; Platelet degranulation; .
ReactomeR-HSA-2029482; Regulation of actin dynamics for phagocytic cup formation; .
ReactomeR-HSA-3928662; EPHB-mediated forward signaling; .
ReactomeR-HSA-399954; Sema3A PAK dependent Axon repulsion; .
SignaLinkP23528; -; .
SIGNORP23528; -; .
ChiTaRSCFL1; human; .
EvolutionaryTraceP23528; -; .
GeneWikiCofilin_1; -; .
GenomeRNAi1072; -; .
PMAP-CutDBP23528; -; .
PROPR:P23528; -; .
ProteomesUP000005640; Chromosome 11; .
BgeeENSG00000172757; -; .
ExpressionAtlasP23528; baseline and differential; .
GenevisibleP23528; HS; .
GOGO:0015629; C:actin cytoskeleton; IEA:InterPro; .
GOGO:0005737; C:cytoplasm; TAS:UniProtKB; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0031012; C:extracellular matrix; IDA:BHF-UCL; .
GOGO:0005615; C:extracellular space; IDA:UniProtKB; .
GOGO:0005925; C:focal adhesion; IDA:UniProtKB; .
GOGO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell; .
GOGO:0016020; C:membrane; IDA:UniProtKB; .
GOGO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell; .
GOGO:0005634; C:nucleus; TAS:UniProtKB; .
GOGO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell; .
GOGO:0031982; C:vesicle; IDA:UniProtKB; .
GOGO:0051015; F:actin filament binding; IDA:UniProtKB; .
GOGO:0030036; P:actin cytoskeleton organization; TAS:ProtInc; .
GOGO:0030042; P:actin filament depolymerization; IDA:UniProtKB; .
GOGO:0007010; P:cytoskeleton organization; IMP:UniProtKB; .
GOGO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB; .
GOGO:0044794; P:positive regulation by host of viral process; IMP:AgBase; .
GOGO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB; .
GOGO:0061001; P:regulation of dendritic spine morphogenesis; IMP:ParkinsonsUK-UCL; .
GOGO:0009615; P:response to virus; IEP:UniProtKB; .
GOGO:0007266; P:Rho protein signal transduction; TAS:ProtInc; .
CDDcd11286; ADF_cofilin_like; 1; .
Gene3D3.40.20.10; -; 1; .
InterProIPR002108; ADF-H; .
InterProIPR029006; ADF-H/Gelsolin-like_dom; .
InterProIPR017904; ADF/Cofilin; .
InterProIPR027234; Cofilin_1; .
PANTHERPTHR11913; PTHR11913; 1; .
PANTHERPTHR11913:SF37; PTHR11913:SF37; 1; .
PfamPF00241; Cofilin_ADF; 1; .
PRINTSPR00006; COFILIN; .
SMARTSM00102; ADF; 1; .
PROSITEPS51263; ADF_H; 1; .



USC-OGP 2-DE database image


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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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